CEACAM1 recognition by bacterial pathogens is species-specific

Internalization of pathogens in mammalian cells via CEACAM1

Recognition of pathogens by plants

Plants must respond appropriately to a broad array of abiotic and biotic factors in the attempt to accumulate nutrient reserves and reach reproductive maturity. To complicate matters, their stockpile of nutrients makes them prime targets for pathogen attack. Phytopathogenic bacteria, fungi, and viruses all make raids on the stockpile, yet most plants are able to remain disease free. Plants have...

Autophagic clearance of bacterial pathogens: molecular recognition of intracellular microorganisms

Autophagy is involved in several physiological and pathological processes. One of the key roles of the autophagic pathway is to participate in the first line of defense against the invasion of pathogens, as part of the innate immune response. Targeting of intracellular bacteria by the autophagic machinery, either in the cytoplasm or within vacuolar compartments, helps to control bacterial proli...

Manipulation of kinase signaling by bacterial pathogens

Bacterial pathogens use effector proteins to manipulate their hosts to propagate infection. These effectors divert host cell signaling pathways to the benefit of the pathogen and frequently target kinase signaling cascades. Notable pathways that are usurped include the nuclear factor κB (NF-κB), mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K)/Akt, and p21-activated...

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition.

The Toll-like receptor (TLR) family consists of phylogenetically conserved transmembrane proteins, which function as mediators of innate immunity for recognition of pathogen-derived ligands and subsequent cell activation via the Toll/IL-1R signal pathway. Here, we show that human TLR9 (hTLR9) expression in human immune cells correlates with responsiveness to bacterial deoxycytidylate-phosphate-...